蛋白磷酸化在控制细胞信号传导中无处不在。纯化和特征化磷酸的改良方法使磷酸化位点数据爆炸性增长，我们现在可以探讨蛋白磷酸化如何发展的。这个问题在本文中已得到解决。（1）酪氨酸残基（可磷酸化）在后生动物的进化中已选择性丢失。（2）快速进化、无序的蛋白质区域中大多数磷酸化位点改变了位置。（生物谷Bioon.com）
生物谷推荐原始出处：
Science 25 September 2009:DOI: 10.1126/science.1180331
Evolving Cell Signals
Mark O. Collins
Protein phosphorylation has emerged as a ubiquitous regulatory switch in cell signaling networks. Improved methods to purify and characterize phosphopeptides have led to an explosion of phosphorylation site data, and we can now explore how protein phosphorylation evolved. This question has been tackled by two studies in this issue. On page 1686, Tan et al. (1) report that tyrosine residues (which can be phosphorylated) have been selectively lost through metazoan evolution. On page 1682, Holt et al. (2) show that most phosphorylation sites shift position in rapidly evolving, disordered regions of proteins.
Proteomic Mass Spectrometry Group, The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
