生物谷报道：复旦大学生物医学研究院细胞分子生物学研究室管坤良教授和赵世民博士在5月2日出版的Cell发表了有关细胞信号传导特异性研究前沿进展综述：Substrate Selectivity APPLies to Akt.
信号传导特异性的研究是目前国际信号传导研究的热点之一。细胞通过复杂的信号“分拣系统”将特定外部刺激产生的信号准确地传达到细胞内的相关功能执行蛋白，而且不改变细胞内其它蛋白的功能，进而达到一种外界刺激只引发特定的生理响应（如细胞的生长、凋亡等）的结果。相关领域的研究突破可能为研制特异的抗癌药物以及开发针对其它疾病的特异性药物带来新的希望。（生物谷www.bioon.com)
生物谷推荐原始出处：
Cell，Vol 133, 399-400，Shimin Zhao，Kun-Liang Guan
Substrate Selectivity APPLies to Akt
Shimin Zhao1 and Kun-Liang Guan2,
1 Laboratory of Molecular and Cellular Biology, Institute of Biomedical Sciences, Fudan University, Shanghai 200032, China
2 Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA
Summary
The protein kinase Akt occupies a central position in multiple signaling pathways. Although numerous Akt substrates have been identified, less is known about the factors that regulate specific cellular responses to Akt signaling. In this issue, Schenck et al., 2008 demonstrate that the endosomal protein Appl1 modulates Akt's substrate selectivity to promote cell survival during zebrafish development.
