近日，一项发表在Bipolar Disorder上的研究"Dimensional psychopathology in offspring of parents with bipolar disorder"指出，与健康父母的孩童相比，罹患双相障碍的父母，其孩童较易出现情感和行为紊乱症状。
来自美国匹兹堡大学的Rasim Diler和他的同事们说道：“年轻人罹患双相障碍，可增加自杀、精神病、物质滥用以及发育和心理社会功能的风险，且这种疾病的确诊时间较晚，这些患者平均需要10年的时间才能得到确诊，进而进行首次治疗。”
本项研究纳入年龄6-18岁的儿童，并分为三组：319例儿童的父母罹患双相障碍，但这些儿童无双相障碍、35例儿童的父母罹患双相障碍，且这些儿童亦被诊断为双相谱系障碍、235例儿童的父母无双相障碍（对照组）。
与对照组相比，双相障碍患儿及罹患双相障碍的父母的孩童的多个评估量表（包括儿童行为量表CBCL）的评分明显增加。与对照组相比，双相障碍父母所生的孩子，较易出现焦虑、抑郁、注意缺陷、激越行为等体征。（生物谷Bioon.com）
相关阅读：
J Affect Disord：心境稳定剂治疗延迟或增自杀风险
doi:10.1111/j.1399-5618.2011.00966.x
PMC:
PMID:
Dimensional psychopathology in offspring of parents with bipolar disorder
Rasim Somer Diler1, Boris Birmaher1, David Axelson1, Mihaela Obreja1, Kelly Monk1, Mary Beth Hickey1, Benjamin Goldstein2, Tina Goldstein1, Dara Sakolsky1, Satish Iyengar3, David Brent1, David Kupfer1
Objectives:To compare the dimensional psychopathology in offspring of parents with bipolar disorder (BP) with offspring of community control parents as assessed by the Child Behavior Checklist (CBCL).
Methods:Offspring of parents with BP, who were healthy or had non-BP disorders (any psychiatric disorder other than BP; n = 319) or who had bipolar spectrum disorders (n = 35), and offspring of community controls (n = 235) ages 6–18 years were compared using the CBCL, the CBCL-Dysregulation Profile (CBCL-DP), and a sum of the CBCL items associated with mood lability. The results were adjusted for multiple comparisons and for any significant between-group demographic and clinical differences in both biological parents and offspring.
Results:With few exceptions, several CBCL (e.g., Total, Internalizing, and Aggression Problems), CBCL-DP, and mood lability scores in non-BP offspring of parents with BP were significantly higher than in offspring of control parents. In addition, both groups of offspring showed significantly lower scores in most scales when compared with offspring of parents with BP who had already developed BP. Similar results were obtained when analyzing the rates of subjects with CBCL T-scores that were two standard deviations or higher above the mean.
Conclusions:Even before developing BP, offspring of parents with BP had more severe and higher rates of dimensional psychopathology than offspring of control parents. Prospective follow-up studies in non-BP offspring of parents with BP are warranted to evaluate whether these dimensional profiles are prodromal manifestations of mood or other disorders, and can predict those who are at higher risk to develop BP.
