?7月13日,费城(UPI)—A U.S.科学家在实验室里成功完成了动物损伤脊髓神经束的再生及其肢体活动的恢复。
??Drexel大学医学院神经生物学与解剖学专家John Houle的实验演示了神经是如何从动物腿部移取并移植到损伤的脊髓束的——由于联合了酶的吸收瘢痕组织作用——从而再生。
??“这项研究对于如何使脊髓神经损伤病人重新恢复到可以活动的状态是一个重要的里程碑”,Houle说,“然而仍有大量的工作要做,以运用到患者身上。”
??他声称该研究一个重要的意义是实验过程既适用于新受伤的动物,也适用于损伤时间较长的动物。
??该研究的第二个重要方面是特殊酶——软骨素酶的修复瘢痕组织、减少其正常抑制状态及促进边缘生长的作用。
??该研究详细内容见于《神经科学》杂志。
英文原文:
Study shows spinal cord regeneration
PHILADELPHIA, July 13 (UPI) -- A U.S. scientist has demonstrated in a lab animal the successful regeneration of injured spinal nerve endings and recovery of arm movements.
John Houle, professor of neurobiology and anatomy at Drexel University College of Medicine, demonstrated how a nerve removed from the animal's leg and transplanted across a spinal cord injury -- in combination with enzyme digestion of scar material -- led to regeneration.
"This study represents a major milestone in the battle to return spinal cord injury patients to a state of mobility," said Houle. "However there is still a lot of work to be done to adapt this procedure to human use."
He said a significant aspect of the study is the process applies to animals that are newly injured, as well as in animals with long-term injuries.
A second facet of the study is the ability of the specific enzyme, chondroitinase, to modify scar tissue, reducing its normal inhibitory nature and facilitating growth beyond the bridge.
The research project is detailed in the Journal of Neuroscience.
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