生物谷按：功能基因组和功能蛋白质组学的研究为人类揭示生命活动的本质提供了强有力的工具，然而我们也应看到当前的研究还存在很大的局限性，如何通过这些复杂数据，采用何种有效的分析策略揭示生物活动的本质特征，揭示细胞活动网络的动力学特征，是未来二十年内科学家思考最多的问题之一。如细胞信号转导根本不是我们现阶段认识的单一途径和模式，也不是线性化的，而是一个复杂调控的网络体系，这个网络体系是一个复杂的动态平衡系统，它能将外界的信息快速有效传递到细胞内，然后对该信号产生应激，同时这个系统会将该刺激信息作为一个信息会记忆和储存在这个系统中。这篇文章提出了初步的看法。
From functional genomics to systems biology: concepts and practices.
Auffray C, Imbeaud S, Roux-Rouquie M, Hood L.
C R Biol. 2003 Oct-Nov;326(10-11):879-92.
Genexpress, Functional Genomics and Systemic Biology for Health, CNRS FRE 2571, 7, rue Guy-Moquet, BP 8, 94801 Villejuif cedex, France. auffray@vjf.cnrs.fr
Systems biology is the iterative and integrative study of biological systems as systems in response to perturbations. It is founded on hypotheses formalized in models built from the results of global functional genomics analyses of the complexity of the genome, transcriptome, proteome, metabolome, etc. Its implementation by cross-disciplinary teams in a standardized mode under quality assurance should allow accessing the small variations of the large number of elements determining functioning of biological systems. Galactose utilization in yeast, and sea urchin development are two examples of emerging systems biology.
