瑞典医学研究人员的最新研究成果显示,乳腺炎与乳腺癌并没有多大的直接关联。
瑞典卡罗林斯卡医学院和瑞典乌普萨拉地区肿瘤防治中心的研究人员近期对8000多名因患严重乳腺炎而住院治疗的妇女进行了跟踪调查。他们发现,被调查妇女中后来有106人患上了乳腺癌,不过在这些乳腺癌患者中发生癌变的乳房只有一半曾患过乳腺炎。研究人员因此认为,乳腺炎与乳腺癌并没有多大的直接关联,乳腺炎直接诱发乳腺癌的危险性并不大。
根据哺乳有助于预防乳腺癌的理论,研究人员还认为,得过乳腺炎的妇女之所以容易患上乳腺癌,主要是因为她们在得了乳腺炎后提前中断了哺乳。
乳腺炎是指乳腺的急性化脓性感染,是产褥期的常见病,迄今其病因尚无权威解释。瑞典研究人员的上述研究成果发表在9月一期的《流行病学》(Epidemiology)期刊上。(生物谷Bioon.com)
生物谷推荐原始出处:
Epidemiology:doi: 10.1097/EDE.0b013e3181adbb1e
Mastitis and the Risk of Breast Cancer
Lambe, Mats; Johansson, Anna L. V.; Altman, Daniel; Eloranta, Sandra
Background: Many cancers arise from sites of infection and inflammation. Results from animal studies indicate that inflammatory cells may facilitate neoplastic processes by orchestrating the tumor microenvironment. Little is known about the role of inflammation in the etiology of breast cancer. The aim of this study was to examine possible associations between a history of mastitis requiring hospitalization and subsequent risk of breast cancer.
Methods: This cohort study of 2,577,565 women used data from several Swedish population-based registers, including the Inpatient Register and the Cancer Register. The risk of breast cancer was assessed by Poisson regression modeling.
Results: We identified 8411 women in the Inpatient Register with a discharge diagnosis of mastitis. Of these, 106 had a subsequent diagnosis of breast cancer recorded in the Cancer Register. Compared with women who had no recorded mastitis, the incidence rate of breast cancer (regardless of laterality) was higher in women with mastitis, with an incidence rate ratio of 1.23 (95% confidence interval [CI] = 1.02-1.49) following adjustment for age, calendar time, age at first birth and parity. In the group of women among whom information on laterality was available for both the mastitis and the malignancy (n = 87), side of lesions corresponded for 52% (95% CI = 41%-62%), which is what could be expected by chance.
Conclusions: The overall risk of breast cancer was slightly elevated in women with a history of mastitis recorded in the Inpatient Register. The absence of a correlation between laterality of lesions, however, does not support a causal association between inflammation and the development of breast cancer.